The U.S. government has subpoenaed Wyeth in connection with its marketing to doctors of the antidepressant drug Effexor, making it the third drug company in a week to receive a subpoena in a widening federal investigation.

James Sheehan, assistant U.S. attorney in Philadelphia, said Wyeth, Johnson & Johnson and Forest Laboratories Inc. have been subpoenaed in a probe related to potentially over-aggressive marketing of psychiatric drugs.

The subpoenas came from the inspector general for the Office of Personnel Management, which investigates potential fraud involving the health benefits of about 10 million federal employees and retirees.