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Behavioral toxicity of
Van Putten T, Marder
Extrapyramidal symptoms cause much misery, often go
undiagnosed, and can interfere with treatment and rehabilitation.
Akinesia is a behavioral state of diminished motoric and psychic
spontaneity that is difficult to distinguish from the negative symptoms
of schizophrenia. The most useful clinical correlates of akinesia are a
subjective sense of sedation and excessive sleeping. Akinesia interferes
with social adjustment and may manifest as "postpsychotic depression."
The subjective restlessness of akathisia is usually accompanied by
telltale foot movements: rocking from foot to foot while standing or
walking on the spot. Akathisia is strongly associated with depression
and dysphoric responses to neuroleptics and has even been linked to
suicidal and homicidal behavior in extreme cases.
PMID: 2887552 [PubMed - indexed for MEDLINE]