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Postmortem concentrations of
citalopram.
Anastos N, McIntyre IM, Lynch MJ,
Drummer OH.
Department of Forensic Medicine, Monash
University, Southbank, Victoria, Australia.
The postmortem
concentrations of citalopram in blood, bile, liver, and vitreous humour
were investigated in 14 cases using a specially developed high
performance liquid chromatography assay. Concentrations from drug and
non-drug related deaths were categorized to determine a postmortem
therapeutic and toxic range. Therapeutic citalopram concentrations for
blood, bile, liver, and vitreous humour ranged to 0.4 mg/L, 2.1 mg/l,
6.6 mg/kg, and 0.2 mg/L, respectively. In one potentially fatal response
to citalopram, concentrations were 0.8 mg/L, 6.0 mg/L, 0.3 mg/L for
blood, bile and vitreous humour, respectively.
Publication Types:
PMID: 12137000 [PubMed - indexed for
MEDLINE]
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