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Impact
of cortisol on buspirone stimulated prolactin release: a double-blind
placebo-controlled study.
Dinan TG, Scott LV, Thakore J, Naesdal J, Keeling PW.
Department of Pharmacology and Therapeutics, University College Cork, The Cork
Clinic, Western Road, Cork, Ireland. tdinan@indigo.ie
Buspirone is known to stimulate prolactin (PRL) release. Clinical studies (e.g.
in chronic fatigue syndrome) suggest that the response may be influenced by
baseline cortisol levels. We conducted a double-blind placebo-controlled study
to examine the relationship between the prolactin response to buspirone
challenge and baseline cortisol level. Fifty healthy volunteers took part in
the study. Buspirone was found to consistently elevate PRL levels
above those seen following placebo administration. The PRL response as measured
by area under the curve was highly correlated with the baseline cortisol
level.
Publication Types:
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Clinical
Trial
·
Randomized
Controlled Trial
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