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Cardiovascular and neurological
toxicity of venlafaxine.
Blythe D, Hackett
Intensive Care Unit, Sir Charles Gairdner Hospital,
Perth, Western Australia.
1. We report a case of venlafaxine
overdose and describe pharmacokinetic data on drug disposition. 2. Case
report. Serial venlafaxine levels were measured and drug half-life
calculated and compared to data at therapeutic concentrations.
Metabolite concentrations were also measured and the potential for
toxicity described with reference to individual variation in such
metabolism 3. Venlafaxine can cause significant cardiac and
neurotoxicity. Its potential for causing such toxicity may be dependent
on whether an individual has the extensive metaboliser cytochrome CYP2D6
phenotype or the poor metaboliser phenotype
PMID: 10372752 [PubMed - indexed for