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1: Ann Pharmacother. 1997 Feb;31(2):178-80.

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Comment in:

• Ann Pharmacother. 1997 Jun;31(6):790-1.
• Ann Pharmacother. 1998 Jan;32(1):135-6.

Seizure resulting from a venlafaxine overdose.

White CM, Gailey RA, Levin GM, Smith T.

Drug Information Center, Hartford Hospital, CT 06102, USA.

OBJECTIVE: To report a case of venlafaxine overdose. CASE SUMMARY: A 40-year-old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt. After the ingestion of 26 venlafaxine 50-mg tablets, the patient experienced a witnessed generalized seizure. She was admitted to the medical intensive care unit, venlafaxine was discontinued, and no further sequelae were seen. DISCUSSION: To our knowledge, this is the first reported case of venlafaxine overdose that resulted in a generalized seizure. Based on nonoverdose pharmacokinetics and pharmacodynamics of venlafaxine and the potential risks of available interventions, no emergent therapy was instituted. CONCLUSIONS: The venlafaxine overdose in our patient resulted in a single episode of generalized seizure but elicited no further sequelae.

Publication Types:

• Case Reports

PMID: 9034419 [PubMed - indexed for MEDLINE]

Jan 29 2004 15:06:34