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Atrium and paroxetine-related
Cadranel JF, Di Martino V, Cazier
A, Pras V, Bachmeyer C, Olympio P, Gonzenbach A, Mofredj A, Coutarel P,
Devergie B, Biour M.
Unite d'Hepatologie, Centre Hospitalier
Laennec, Creil, France.
Two cases of severe hepatitis in young
women using Atrium and paroxetine are presented. Both patients presented
jaundice, marked increase in aminotransferases activities, and
pronounced prolongation in prothrombin time. In both cases, liver biopsy
specimen examination revealed lesions compatible with drug-related
injury. Other causes of hepatic injury were reasonably ruled out by
complete careful screening. Outcome was marked by rapid complete
recovery in one case and by slow recovery in the other. We suggest that
simultaneous treatment with Atrium and paroxetine could increase each of
these drugs' hepatotoxicity.
PMID: 9916669 [PubMed - indexed for