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The Netherlands Journal of Medicine
Volume 50, Issue 6 , June 1997, Pages 243-245

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doi:10.1016/S0300-2977(97)00005-3    How to Cite or Link Using DOI (Opens New Window)  

Syndrome of inappropriate ADH secretion attributed to the serotonin re-uptake inhibitors, venlafaxine and paroxetine

I. A. Meynaara, *, A. J. Peetersa, A. H Muldera and J. P. Ottervangerb

a Department of Internal Medicine, Reinier de Graaf Gasthuis, R. de Graafweg 3 2625 AD Delft Netherlands
b Netherlands Centre for Monitoring of Adverse Reactions to Drugs, PO Box 5406 2280 HK Rijswijk Netherlands

Received 27 March 1996; revised 4 December 1996; accepted 11 December 1996. Available online 5 February 1998.


Abstract

We report on 2 patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) which developed a few weeks after they had started treatment with venlafaxine and paroxetine, respectively. Due to the temporal relationship and the exclusion of other potential causes, a causal relationship between the use of the antidepressants and SIADH seems likely. Diagnostic criteria for SIADH and the role of drugs, especially serotonin re-uptake inhibitors, are discussed.

Author Keywords: Venlafaxine; Paroxetine; SIADH; Hyponatraemia; Antidepressants

Index Terms: inappropriate vasopressin secretion; depression; venlafaxine; paroxetine; serotonin uptake inhibitor


*Corresponding author.



This Document
Abstract
PDF (191 K)
Actions
E-mail Article
The Netherlands Journal of Medicine
Volume 50, Issue 6 , June 1997, Pages 243-245


 
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