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Comment in:
Serotonin syndrome
associated with nefazodone and paroxetine.
John L,
Perreault MM, Tao T, Blew PG.
Department of Pharmacy, Ottawa
General Hospital, Ontario, Canada.
A 51-year-old woman was
brought to the emergency department unresponsive, hyponatremic, and
diaphoretic, with muscle rigidity. Her condition improved dramatically
after supportive treatment and dantrolene. The patient had received
nefazodone for 6 months, but the drug had been discontinued 2 days
before admission after a tapering period. One day before admission,
paroxetine 20 mg/day was started. A repeat challenge with paroxetine 7
days after discontinuation of nefazodone did not result in recurrence of
the patient's symptoms. We believe this to be the first report of
serotonin syndrome associated with nefazodone and
paroxetine.
Publication Types:
PMID: 9018197 [PubMed - indexed for
MEDLINE]
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