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associated with nefazodone and paroxetine.
Perreault MM, Tao T, Blew PG.
Department of Pharmacy, Ottawa
General Hospital, Ontario, Canada.
A 51-year-old woman was
brought to the emergency department unresponsive, hyponatremic, and
diaphoretic, with muscle rigidity. Her condition improved dramatically
after supportive treatment and dantrolene. The patient had received
nefazodone for 6 months, but the drug had been discontinued 2 days
before admission after a tapering period. One day before admission,
paroxetine 20 mg/day was started. A repeat challenge with paroxetine 7
days after discontinuation of nefazodone did not result in recurrence of
the patient's symptoms. We believe this to be the first report of
serotonin syndrome associated with nefazodone and
PMID: 9018197 [PubMed - indexed for