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1: J Toxicol Clin Toxicol. 1997;35(1):93-5. Related Articles, Links

Comment in:
Syndrome of inappropriate secretion of antidiuretic hormone in two elderly women with elevated serum fluoxetine.

Girault C, Richard JC, Chevron V, Goulle JP, Droy JM, Bonmarchand G, Leroy J.

Medical Intensive Care Unit, Charles Nicolle University Hospital, Rouen, France.

OBJECTIVE: Fluoxetine is widely prescribed for depressed patients. Hyponatremia secondary to inappropriate secretion of antidiuretic hormone has been reported in a few cases associated with routine use of fluoxetine, especially in elderly patients. The mechanism has been postulated to be linked to the inappropriate secretion of antidiuretic hormone. Serum concentrations of antidiuretic hormone and fluoxetine have not been reported in previously published reports. CASE REPORT: We report two new cases of severe and reversible hyponatremia associated with routine use of fluoxetine therapy in two elderly women. Fluoxetine-induced inappropriate secretion of antidiuretic hormone was confirmed by elevated serum concentrations of antidiuretic hormone and fluoxetine.

Publication Types:
  • Case Reports

PMID: 9022659 [PubMed - indexed for MEDLINE]


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