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Comment in:
Fluoxetine and the syndrome of inappropriate secretion of
antidiuretic hormone (SIADH)
Burke D, Fanker
S.
Department of Aged Care, St George Hospital, Kogarah, New
South Wales, Australia.
OBJECTIVE: To report three new cases of
the fluoxetine-induced syndrome of inappropriate secretion of
antidiuretic hormone (SIADH). CLINICAL PICTURE: All three cases occurred
in elderly psychiatric inpatients treated for depression with standard
doses of fluoxetine within one month of starting the medication. All
three patients were clinically symptomatic of SIADH. TREATMENT: In all
three patients the medication was ceased and fluid restriction
commenced. One patient required intravenous saline. OUTCOME: All three
patients recovered fully within three weeks. None were rechallenged.
CONCLUSIONS: The symptoms of hyponatraemia due to fluoxetine-induced
SIADH may be difficult to distinguish from the symptoms of depression,
unless appropriate laboratory investigations are
made.
Publication Types:
- Case Reports
- Review
- Review of Reported Cases
PMID: 8811276 [PubMed -
indexed for MEDLINE]
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