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fluoxetine-induced frontal lobe syndrome in an obsessive compulsive
Hoehn-Saric R, Harris GJ, Pearlson GD, Cox
CS, Machlin SR, Camargo EE.
Johns Hopkins Medical
Institutions Department of Psychiatry and Behavioral Sciences,
Baltimore, MD 21205.
The authors report the occurrence of apathy,
indifference, inattention, and perseveration in an obsessive compulsive
patient taking high doses of fluoxetine. These changes were associated
with a decrease in cerebral blood flow in the frontal lobes and changes
in neuropsychological tests generally associated with frontal lobe
impairment. These clinical manifestations disappeared 4 weeks after
discontinuation of fluoxetine.
PMID: 2005077 [PubMed - indexed for