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Mirtazapine induces REM
sleep behavior disorder (RBD) in
Onofrj M, Luciano AL, Thomas A,
Iacono D, D'Andreamatteo G.
Department of Oncology and
Neuroscience, University G. D'Annunzio, Pescara, Italy.
Shortly after initiation of mirtazapine (a
noradrenergic and serotonergic antidepressant) treatment in four
patients with parkinsonism, the authors observed the appearance of REM
sleep behavior disorder (RBD). In the two patients with severe motor
symptoms, RBD was accompanied by hallucinations and confusion. These
disturbances resolved with drug discontinuation, and remained resolved
by 12- to 24-month follow-up, suggesting that RBD can be triggered by a
drug lacking anticholinergic activity.
PMID: 12525729 [PubMed - indexed for