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Serotonin and the regulation of
pituitary hormone secretion and of neuroendocrine
rhythms.
Kordon C, Hery M, Szafarczyk A, Ixart G,
Assenmacher I.
The importance of 5-HT [serotonin] synaptic transmission
for induced or cyclic activation of pituitary secretion now seems widely
agreed upon. Raphe structures, the suprachiasmatic nucleus, and,
hypothetically, identified mesencephalic 5-HT containing neurons can be
assumed to represent parts of the neuronal circuitry of a central clock
which synchronizes neuroendocrine rhythms. Cyclic input from the pineal
gland may also be involved, though the meaning of this has not yet been
clearly established. The primary role of the transmitter may be to
modulate transmission to neurosecretory neurons at the output of this
clock. This modulation is not hormone-specific and affects,
simultaneously, several endocrine functions. 5-HT has also been shown to
facilitate the pituitary response to discrete neuroendocrine reflexes,
such as the suckling-induced release of prolactin. 5-HT interactions
with hormone control provide a good illustration of the neuromodulatory
role of the amine.
PMID: 7288660 [PubMed - indexed for MEDLINE]
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