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Harris CR, Gualtieri J, Stark
Emergency Medicine Department, Ramsey Medical Center, St.
Paul, MN 55101-2595, USA. firstname.lastname@example.org
Bupropion is a unique monocyclic antidepressant that has been known to
cause seizures in high therapeutic doses and in acute overdoses. Death
due to ingestion, however, is a rare occurrence. CASE REPORT: We report
a case of a 26-year-old man who ingested 23 g bupropion, developed
seizures and hypoxia, and presented in cardiac arrest. The patient was
resuscitated in the emergency department, but died 4 d after supportive
intensive care. CONCLUSIONS: Bupropion overdose may lead to recurrent
seizures, hypoxia and death. Aggressive management of severe bupropion
overdose is recommended.
PMID: 9140330 [PubMed - indexed for