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Seizure associated with sleep
deprivation and sustained-release bupropion.
CA, Duckrow RB.
Department of Medicine and Obstetics and
Gynecology, University of Connecticut School of Medicine, University of
Connecticut Health Center, Farmington, Connecticut 06030-3940, USA.
This case report describes a generalized
seizure associated with sustained-release bupropion use and sleep
deprivation. The subject, a 31-year-old female smoker, was participating
in a clinical trial evaluating an investigational medication for smoking
cessation that used sustained-release bupropion as an active control.
After 5 weeks of bupropion use, the subject experienced a generalized
tonic clonic seizure after staying up nearly all night packing and
moving to a new residence. The patient had no other risk factors for
seizures. We suggest that sleep deprivation may add to the risk of
PMID: 12745515 [PubMed - indexed for