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Serotonin syndrome in a child
associated with erythromycin and sertraline.
DO, Lee CD.
Department of Psychiatry, Emory University School
of Medicine, Atlanta, Georgia, USA.
Serotonin syndrome is an
uncommon, serious adverse reaction that is usually associated with the
interaction of two or more serotonergic agents. A 12-year-old boy
receiving sertraline developed the syndrome after erythromycin was added
to his regimen. The proposed mechanism involves erythromycin
inactivation of cytochrome P450 3A4 inhibition of sertraline metabolism,
accumulation of the drug, and precipitation of the syndrome. It is
important for clinicians to consider both pharmacokinetic and
pharmacodynamic interactions to minimize the risk of the
PMID: 10417041 [PubMed - indexed for