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1: Blood Coagul Fibrinolysis. 2003 Jan;14(1):77-8. Related Articles, Links
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Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome after bupropion treatment for smoking cessation.

Mele L, Voso MT, Fianchi L, Leone G, Pagano L.

Instituto di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy.

Bupropion hydrochloride is an effective drug for people who want stop smoking, and its use has recently increased in many countries. The main side effects of this drug are related to its dopaminergic activity and are dose dependent. To date, no cases of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) have been reported in literature. Here we describe a case of a woman who developed a sporadic form of TTP-HUS during a treatment with bupropion for smoking cessation, successfully treated with plasma ex-change therapy. The authors wish to make readers aware of bupropion as a possible cause of this potentially lethal disease. Copyright 2003 Lippincott Williams & Wilkins

Publication Types:
  • Case Reports

PMID: 12544732 [PubMed - indexed for MEDLINE]