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Emergence of intense suicidal preoccupation during fluoxetine treatment.

Teicher MH, Glod C, Cole JO.

Department of Psychiatry, Harvard Medical School, MA.

Six depressed patients free of recent serious suicidal ideation developed intense, violent suicidal preoccupation after 2-7 weeks of fluoxetine treatment. This state persisted for as little as 3 days to as long as 3 months after discontinuation of fluoxetine. None of these patients had ever experienced a similar state during treatment with any other psychotropic drug.