06-05-2002 By Carol
Editor’s Note: This information is based on tapes of
Carol Sieverling’s October 2000 patient visit with Dr.
Cheney. He gave permission to share this information,
but has not reviewed or edited it.
Dr. Cheney recently came across some information
regarding the dangers of Selective Serotonin Reuptake
Inhibitors (SSRIs), such as Prozac, Zoloft and Paxil,
and stimulants like Ritalin and Provigil. During office
visits, Dr. Cheney shows patients the book Prozac
Backlash: Overcoming the Dangers of Prozac, Zoloft,
Paxil and Other Antidepressants by Joseph Glenmullen,
M.D., a psychiatrist at Harvard Medical School. It
includes endorsements from other Ivy League
psychiatrists. Cheney calls the implications of this
When talking with patients, Cheney usually opens the
book to a picture of a monkey's brain before and after
it received a very potent SSRI. The "before" photo shows
a dark background filled with fine white lines and white
blobs, healthy neurons. The "after" photo is very dark,
only a few white lines and blobs remain. Most of the
brain cells had been "fried."
SSRIs and stimulants work by increasing the firing of
neurons. While this often has great benefits in the
short term, doctors are now realizing that long term use
"fries" brain cells. The body views any neuron that
fires excessively over time as damaged, and destroys it.
SSRIs and stimulants, taken over a period of 10 years
or so, can lead to a loss of brain cells, causing
neurodegenerative disorders. Many doctors have recently
seen a sudden increase in patients with neurological
symptoms, and most have been on Prozac, or a similar
drug, for about 10 years. Cheney is seeing this in his
During office visits, Cheney also shows patients a
copy of the May 22, 2000 issue of Newsweek with Michael
J. Fox on the cover. It has an excellent article on
Parkinson's Disease, a condition that involves a loss of
neurons in the area associated with motor control.
Parkinson's drugs stimulate the remaining neurons to
"perform heroically," firing excessively. However, the
article notes that while benefits are seen initially,
neurological symptoms get much worse at the three to
five-year point. Patients experience wild involuntary
movements, etc. These drugs, though helpful in the short
term, actually speed up the degenerative process.
What mechanisms are at work causing neurons to be
"fried?" SSRIs are often prescribed for depression,
which involves a lack of serotonin. Serotonin is a
neurotransmitter, a chemical messenger. One neuron
releases a burst of it into the intersynaptic cleft,
(the gap between neurons). The serotonin is then taken
up by special receptors in the adjacent neuron. Thus a
message is sent from one neuron to another, with
serotonin carrying the message across the gap. Excess
serotonin is cleared away before a new message is sent.
A "reuptake channel" in one neuron vacuums up the left
SSRIs are designed to address a lack of serotonin by
blocking the reuptake channel from vacuuming up excess
serotonin. While this allows more serotonin to connect
with the receptors, often too much is left floating in
the intersynaptic cleft. The only way the body can get
rid of this excess serotonin is to oxidize it.
Unfortunately, this turns it into a toxic compound that,
over time, kills both the sending and receiving neurons.
Cheney stated, "What starts out as an attempt to
increase serotonin and reduce symptoms ends up with the
destruction of the serotonergic system itself. It takes
about a decade, more in some, less in others.
Now when the serotonergic nerves are dead, you start
getting these motor neuron problems, which is what we're
seeing." Cheney commented, "You know what a lot of
doctors (who do not understand CFIDS) are doing? They're
saying 'Well, let's just give them an antidepressant'.
And they are frying their (patients') brains and they
don't even know it. In fact, a CFIDS patient on one of
these drugs fries their brain even faster than a
non-CFIDS person." (See the article on Klonopin for an
Cheney went on to say, "The other way some people
with CFIDS are going is stimulating the brain, using
drugs like Ritalin or Provigil. They do the same thing -
they fry the brain. They cause neurons to fire at lower
stimulus by lowering the firing threshold. All
stimulants are dangerous, especially over the long haul.
I'm not saying that you might not find them useful in
the short-term. But over the long term, the physiology
demands that neurons that fire excessively be killed."
Cheney strongly urges anyone taking antidepressants
or stimulants to read Glenmullen's book, which lists
safe alternatives to SSRIs.
© 2002 Carol Sieverling. Reprinted with permission.
Related Cheney Article:
Paul Cheney Discusses the Benefits of Klonopin