Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
Privacy Policy
|
 |
-
Increased Brain GABA
Concentrations Following Acute Administration of a Selective Serotonin
Reuptake Inhibitor.
Bhagwagar Z, Wylezinska M,
Taylor M, Jezzard P, Matthews PM, Cowen PJ.
OBJECTIVE: The
authors used magnetic resonance spectroscopy (MRS) to assess the effect
of acute administration of the selective serotonin reuptake inhibitor
(SSRI) citalopram on cortical levels of gamma-aminobutyric acid (GABA).
METHOD: Ten healthy volunteers received either intravenous citalopram
(10 mg) or saline in a randomized, double-blind, crossover design. The
occipital GABA/creatine ratio was measured with a proton MR spectral
editing technique. RESULTS: In comparison with saline, citalopram
produced a mean increase of 35% in relative brain GABA concentration in
the occipital cortex. CONCLUSIONS: These findings extend previous work
showing that SSRI treatment increases cortical GABA in depressed
patients and suggest that this results from an action of SSRIs on GABA
neurons rather than as a secondary consequence of mood
improvement.
PMID: 14754790 [PubMed - in process]
|