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Antidepressant drugs appear to
enhance cocaine-induced toxicity.
O'Dell LE, George
FR, Ritz MC.
Amethyst Technologies, Inc. Scottsdale, Arizona
It has been shown that cocaine-induced
convulsions and lethality appear to be mediated by serotonin and
dopamine neurotransmission, respectively. However, many antidepressants
considered for treatment of cocaine addiction target these monoamine
systems and may thus amplify these toxic effects during relapse. In this
study, the authors assessed whether pretreatment with antidepressants
influences cocaine-induced toxicity in mice as well as the potency of
these medications at cocaine-binding sites previously shown to be
associated with cocaine toxicity. Overall, selective serotonin reuptake
inhibitors (SSRIs) facilitated cocaine-induced convulsions but not
lethality. Dopamine uptake inhibition facilitated cocaine-induced
lethality, but not convulsion. The SSRI sertraline enhanced neither
convulsions nor lethality and may be unique due to its high affinity for
sigma receptors. These results have important implications for safe and
effective addiction treatments.
PMID: 10743914 [PubMed - indexed