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Neonatal complications after
intrauterine exposure to SSRI antidepressants.
[No
authors listed]
(1) Newborns exposed to selective serotonin
reuptake inhibitor (SSRI) antidepressants towards the end of pregnancy
sometimes show signs of agitation, altered muscle tone, and breathing
and suction problems. Similar symptoms can occur after exposure to
tricyclic antidepressants. (2) These neonatal symptoms have been noted
with all five SSRI antidepressants available in France, namely
citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline. (3) An
estimated 20% to 30% of newborns exposed to an SSRI towards the end of
pregnancy are affected. (4) The symptoms are variously attributed to
withdrawal or to the drug itself. (5) In practice, doctors should be
aware of this risk when considering antidepressant treatment for women
in the third trimester of pregnancy. There is no consensus on the
treatment of affected newborns, but close monitoring is
mandatory.
PMID: 15233148 [PubMed - indexed for MEDLINE]
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