Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
Privacy Policy
|
 |
-
Excretion of citalopram in breast
milk.
Spigset O, Carieborg L, Ohman R, Norstrom
A.
Division of Clinical Pharmacology, Norrland University
Hospital, Umea, Sweden.
AIMS: The objective of this study was to
measure to secretion of the selective serotonin uptake inhibitor
citalopram in breast milk. METHODS: The excretion of citalopram in
breast milk was studied at steady-state conditions in two patients with
depression and in one healthy volunteer after ingestion of a single dose
citalopram. RESULTS: Milk/serum concentration ratios based on single
pairs of samples from the two patients ranged from 1.16 to 1.88. Based
on milk concentration data from the patients, the absolute dose ingested
by a suckling infant would be 4.3-17.6 micrograms kg-1 day-1, and the
relative dose 0.7-5.9% of the weight-adjusted maternal dose. Based on
area-under-the-time-concentration curves from the healthy volunteer, the
milk/serum ratio was 1.00, the absolute dose to the infant during
steady-state conditions would be 11.2 micrograms kg-1 day-1 and the
relative dose 1.8% of the weight-adjusted maternal dose. CONCLUSION: The
study shows that the relative dose to a suckling infant is close to that
reported for fluoxetine, and higher than reported for fluvoxamine,
paroxetine and sertraline.
PMID: 9296327 [PubMed - indexed for
MEDLINE]
|