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An unusual multiple drug
intoxication case involving citalopram.
Fu K,
Konrad RJ, Hardy RW, Brissie RM, Robinson CA.
Department of
Pathology and Laboratory Medicine, University of Alabama at Birmingham,
35233-7331, USA.
A 47-year-old male with a history of drug abuse
and suicide attempts was found dead at home. The death scene
investigation showed evidence of cocaine abuse and multiple drug
ingestion. Citralopram, a new selective serotonin reuptake inhibitor,
cocaine, oxycodone, promethazine, propoxyphene, and norpropoxyphene were
identified and quantitated in the postmortem samples by gas
chromatography-mass spectrometry. The concentration of citalopram in the
femoral blood was 0.88 mg/L. The heart blood concentration was 1.16
mg/L. Femoral blood concentrations of the other drugs were as follows:
cocaine, 0.03 mg/L; oxycodone, 0.06 mg/L; promethazine, 0.02 mg/L;
propoxyphene, 0.02 mg/L; and norpropoxyphene, 0.07 mg/L. Other tissue
samples were also analyzed. The concentrations of cocaine, oxycodone,
promethazine, and propoxyphene in the blood, liver, brain, and gastric
contents did not suggest an intentional overdose. However, the
possibility of multiple drug interactions including citalopram was
evident. In this case, the citalopram concentrations were consistent
with those reported in fatal cases involving multiple drug use.
Citalopram was present in urine at a concentration of 0.9
mg/L.
Publication Types:
PMID: 11043674 [PubMed - indexed for
MEDLINE]
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