Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
Privacy Policy
|
 |
-
Premature ejaculation
associated with citalopram withdrawal.
Adson DE,
Kotlyar M.
Department of Psychiatry, School of Medicine,
University of Minnesota, Minneapolis, MN, USA.
adson001@umn.edu
OBJECTIVE: To report a case of premature
ejaculation occurring subsequent to citalopram discontinuation.CASE
SUMMARY: A 43-year-old white man being treated for depression with
citalopram wished to discontinue treatment. Four or 5 days after
stopping citalopram he reported that, during sexual intercourse, his
genitals seemed to be extremely sensitive and orgasm was achieved within
approximately 1 minute. These symptoms continued over the next 3-4 weeks
and remitted after citalopram was restarted. Several subsequent attempts
to discontinue citalopram resulted in a return of these symptoms despite
using a slow tapering regimen. An objective causality assessment
revealed a probable relationship between drug withdrawal and the
observed symptoms.DISCUSSION: The ability of selective
serotonin-reuptake inhibitors (SSRIs) to delay ejaculation has been well
documented; however, discontinuation of these agents generally results
in a return to baseline function. Although discontinuation of SSRI
therapy has been associated with a number of withdrawal symptoms, this
is the first report (MEDLINE, September 2003), to our knowledge, of the
emergence of sexual adverse effects in someone with no previous history
of these symptoms.CONCLUSIONS: Premature ejaculation is a possible
withdrawal effect after SSRI discontinuation. Since patients are usually
reluctant to spontaneously report sexual adverse effects, it is
important to specifically inquire about them both when starting and
stopping treatment with an SSRI.
PMID: 14632589 [PubMed - in
process]
|