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[Delirium during withdrawal of
venlafaxine]
[Article in Dutch]
van Noorden
MS, Vergouwen AC, Koerselman GF.
Sint Lucas Andreas
Ziekenhuis, afd. Psychiatrie, Postbus 9243, 1006 AE Amsterdam.
A
35-year-old man with anxiety and depression who was treated with
venlafaxine, 300 mg a day, developed severe withdrawal symptoms in the
form of a delirium during gradual tapering of the dosage. The symptoms
resolved when the dosage was kept constant and did not recur when the
dosage was reduced more gradually. Withdrawal symptoms are common during
discontinuation of antidepressants, particularly after prolonged use of
agents with a short half-life. The symptoms are usually mild and
transient, especially in the case of selective serotonin reuptake
inhibitors and venlafaxine. The occurrence of delirium as a result of
the withdrawal of venlafaxine has not been reported previously. Even
when antidepressants are being withdrawn with care, one should remain
alert to the possible development of severe withdrawal
symptoms.
Publication Types:
PMID: 12132141 [PubMed - indexed for
MEDLINE]
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