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1: Ann Pharmacother. 1998 Jan;32(1):49-51. Related Articles, Links

Comment in: Click here to read 
Hyponatremia with venlafaxine.

Masood GR, Karki SD, Patterson WR.

Long Term Care Division, Clifton Springs Hospital and Clinic, NY, USA.

OBJECTIVE: To describe a patient with hyponatremia associated with venlafaxine therapy. CASE SUMMARY: A 92-year old white woman who was receiving venlafaxine for management of depression was found to have hyponatremia. A detailed workup confirmed the diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH). A temporal relationship between initiation of venlafaxine therapy and the onset of hyponatremia indicated it as the probable cause. Venlafaxine was discontinued, and hyponatremia resolved with a few weeks. DISCUSSION: Hyponatremia has been reported with selective serotonin-reuptake inhibitors (SSRIs). Serotonin has been reported to elevate concentrations of vasopressin in animal models. Venlafaxine is a potent inhibitor of serotonin reuptake and may have adverse effects similar to those of SSRIs. CONCLUSIONS: We report a case of hyponatremia probably caused by venlafaxine. Awareness of this potential problem would be helpful to clinicians and should be considered in the differential diagnosis of hyponatremia.

Publication Types:
  • Case Reports

PMID: 9475820 [PubMed - indexed for MEDLINE]