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Comment in:
Hyponatremia with
venlafaxine.
Masood GR, Karki SD, Patterson
WR.
Long Term Care Division, Clifton Springs Hospital and
Clinic, NY, USA.
OBJECTIVE: To describe a patient with
hyponatremia associated with venlafaxine therapy. CASE SUMMARY: A
92-year old white woman who was receiving venlafaxine for management of
depression was found to have hyponatremia. A detailed workup confirmed
the diagnosis of syndrome of inappropriate antidiuretic hormone
secretion (SIADH). A temporal relationship between initiation of
venlafaxine therapy and the onset of hyponatremia indicated it as the
probable cause. Venlafaxine was discontinued, and hyponatremia resolved
with a few weeks. DISCUSSION: Hyponatremia has been reported with
selective serotonin-reuptake inhibitors (SSRIs). Serotonin has been
reported to elevate concentrations of vasopressin in animal models.
Venlafaxine is a potent inhibitor of serotonin reuptake and may have
adverse effects similar to those of SSRIs. CONCLUSIONS: We report a case
of hyponatremia probably caused by venlafaxine. Awareness of this
potential problem would be helpful to clinicians and should be
considered in the differential diagnosis of
hyponatremia.
Publication Types:
PMID: 9475820 [PubMed - indexed for
MEDLINE]
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