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1: Eur Respir J. 2000 Jan;15(1):205-8. Related Articles, Links

Erratum in:
  • Eur Respir J 2000 Mar;15(3):627.

Eosinophilic pneumonia and respiratory failure associated with venlafaxine treatment.

Fleisch MC, Blauer F, Gubler JG, Kuhn M, Scherer TA.

Dept of Internal Medicine, Triemli Hospital, Zurich, Switzerland.

Drugs are well known causes of eosinophilic lung disease. In many patients, symptoms increase slowly, pulmonary infiltrates and eosinophilia progress over weeks, and resolve upon withdrawal of the offending agent. Rarely, the disease presents like acute eosinophilic pneumonia with acute onset of symptoms and rapidly progressing infiltrates which may be associated with respiratory failure. This report describe a case of venlafaxine-induced acute eosinophilic pneumonia causing respiratory insufficiency that rapidly resolved upon institution of corticosteroid treatment. This 5-hydroxytryptamine and noradrenaline reuptake inhibitor was previously not known to cause lung or peripheral blood eosinophilia. Considering the increasing use of this class of medication physicians have to be aware of this life-threatening and fully reversible complication.

Publication Types:
  • Case Reports

PMID: 10678647 [PubMed - indexed for MEDLINE]