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Two fatal cases of venlafaxine
poisoning.
Parsons AT, Anthony RM, Meeker
JE.
Laboratory of Forensic Services, Sacramento, California
95820, USA.
Venlafaxine is a phenethylamine derivative that has
recently been approved for use in the treatment of depression. It is
chemically unrelated to tricyclic, tetracyclic, or other available
antidepressant agents. Anticholinergic, hypotensive, hypertensive, and
cardiotoxic side effects are rare. Two fatal cases encountered at
separate laboratories are discussed, both involve high levels of
venlafaxine. Concentrations of the drug in peripheral blood, heart
blood, urine, vitreous humor, and liver are reported. Descriptions of
extraction and gas chromatographic methods for confirmation and
quantitation are included.
Publication Types:
PMID: 8835666 [PubMed - indexed for
MEDLINE]
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