Syndrome of inappropriate ADH secretion attributed to the serotonin re-uptake
inhibitors, venlafaxine and paroxetine
I. A. Meynaara,
*,
A. J. Peetersa,
A. H Muldera
and J. P. Ottervangerb
a Department of Internal Medicine,
Reinier de Graaf Gasthuis, R. de Graafweg 3 2625 AD Delft Netherlands
b Netherlands Centre for Monitoring of Adverse
Reactions to Drugs, PO Box 5406 2280 HK Rijswijk Netherlands
Received 27
March 1996; revised 4 December 1996; accepted 11 December 1996. Available online
5 February 1998.
Abstract
We report on 2 patients with the syndrome of inappropriate secretion of
antidiuretic hormone (SIADH) which developed a few weeks after they had started
treatment with venlafaxine and paroxetine, respectively. Due to the temporal
relationship and the exclusion of other potential causes, a causal relationship
between the use of the antidepressants and SIADH seems likely. Diagnostic
criteria for SIADH and the role of drugs, especially serotonin re-uptake
inhibitors, are discussed.
Author Keywords: Venlafaxine; Paroxetine; SIADH;
Hyponatraemia; Antidepressants
Index Terms: inappropriate vasopressin secretion;
depression; venlafaxine; paroxetine; serotonin uptake inhibitor
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