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An organic psychosis due to a
venlafaxine-propafenone interaction.
Pfeffer F,
Grube M.
Klinik fur Psychiatrie und Psychotherapie der
Stadtischen Kliniken a M-Hochst, Frankfurt, Germany.
OBJECTIVE:
An extraordinary case of an organic psychosis during the treatment of a
patient with a bipolar affective disorder. METHODS: Clinical observation
and further investigations including monitoring of serum levels (case
report). RESULTS: A significant interaction between venlafaxine and
propafenone causes markedly increased serum levels of venlafaxine
correlating with unexpected psychopathological changes. CONCLUSIONS:
There is a potentially dangerous interaction between venlafaxine and
propafenone. Serum levels of venlafaxine should be monitored if
propafenone is added.
Publication Types:
PMID: 11949740 [PubMed - indexed for
MEDLINE]
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