Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
Privacy Policy
|
 |
-
Sleep changes after 4 consecutive
days of venlafaxine administration in normal
volunteers.
Salin-Pascual RJ, Galicia-Polo L,
Drucker-Colin R.
Servicio de Investigacion del Hospital
Psiquiatrico Fray Bernardino Alvarez, Departamento de Fisiologia,
Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico
City.
BACKGROUND: The purpose was to examine the effect of the
antidepressant drug venlafaxine on sleep architecture and periodic leg
movements of sleep (PLMS) in normal volunteers. METHOD: Eight normal
volunteers were studied under laboratory sleep conditions as follows: 1
acclimatization night, 1 baseline night, and 4 consecutive nights of
venlafaxine p.o. administration (75 mg during the first 2 nights and 150
mg the last 2 nights). RESULTS: Venlafaxine increased both wake time and
sleep stage I. Sleep stages II and III were reduced. REM sleep time was
reduced after the first venlafaxine dose, and, by the fourth night, REM
sleep was completely suppressed in all volunteers. Six of the eight
volunteers showed PLMS at a frequency above 25 per hour. CONCLUSION:
Venlafaxine produces several sleep disturbances, which include abnormal
leg movements.
PMID: 9515972 [PubMed - indexed for MEDLINE]
|