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Claudia Peano, MD* [MEDLINE LOOKUP] Jerrold B Leikin, MD‡ [MEDLINE LOOKUP] Paul K Hanashiro, MD§ [MEDLINE LOOKUP]

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Abstract

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Few cases of overdoses have been described involving venlafaxine, lamotrigine, or a combination of the two agents. We describe a combined venlafaxine and lamotrigine ingestion in a patient presenting with a seizure, ventricular tachycardia, and rhabdomyolysis. We conclude that patients with overdoses that involve venlafaxine can exhibit severe cardiac effects in addition to seizures, especially if venlafaxine is combined with other agents.
[Peano C, Leikin JB, Hanashiro PK: Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine. November Ann Emerg Med 1997;30:704-708.]

Publishing and Reprint Information

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• From the Department of Nephrology, Rush Presbyterian St. Luke’s Medical Center,^* Illinois Poison Center, Rush Medical College,^‡ and Department of Emergency Services, Rush Medical College, Chicago, IL.^§
• Received for publication October 14, 1996.
  
• Revisions received February 5, 1997.
  
• Accepted for publication April 29, 1997.
• Presented at the North American Congress of Clinical Toxicology, Portland, Oregon, October 10-15, 1996.
  
• Reprint no. 47/1/83298
  
• Address for reprints: Jerrold B Leikin, MD, Emergency Services, 1653 W Congress Parkway, Chicago, IL 60612
  

• Copyright © by the American College of Emergency Physicians.