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November 1997 • Volume 30 • Number 5

Seizures, Ventricular Tachycardia, and Rhabdomyolysis as a Result of Ingestion of Venlafaxine and Lamotrigine

Claudia Peano, MD* [MEDLINE LOOKUP]
Jerrold B Leikin, MD‡ [MEDLINE LOOKUP]
Paul K Hanashiro, MD§ [MEDLINE LOOKUP]
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Few cases of overdoses have been described involving venlafaxine, lamotrigine, or a combination of the two agents. We describe a combined venlafaxine and lamotrigine ingestion in a patient presenting with a seizure, ventricular tachycardia, and rhabdomyolysis. We conclude that patients with overdoses that involve venlafaxine can exhibit severe cardiac effects in addition to seizures, especially if venlafaxine is combined with other agents.
[Peano C, Leikin JB, Hanashiro PK: Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine. November Ann Emerg Med 1997;30:704-708.]

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