Serotonin syndrome, a potentially fatal iatrogenic complication of
psychopharmacologic therapy, is most commonly reported with combinations of
serotonergic medications. Serotonin syndrome is characterized by alterations in
cognition, behavior, autonomic, and central nervous system function as a result
of increased postsynaptic serotonin receptor agonism. We present the first
reported case of serotonin syndrome after a single dose of fluvoxamine in a
pediatric patient after ingestion of a single supratherapeutic dose of
fluvoxamine. [Gill M, LoVecchio F, Selden B: Serotonin syndrome in a child after
a single dose of fluvoxamine. Ann Emerg Med April 1999;33:457-459.]