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1: J Clin Gastroenterol. 1999 Jan;28(1):52-5. Related Articles, Links

Atrium and paroxetine-related severe hepatitis.

Cadranel JF, Di Martino V, Cazier A, Pras V, Bachmeyer C, Olympio P, Gonzenbach A, Mofredj A, Coutarel P, Devergie B, Biour M.

Unite d'Hepatologie, Centre Hospitalier Laennec, Creil, France.

Two cases of severe hepatitis in young women using Atrium and paroxetine are presented. Both patients presented jaundice, marked increase in aminotransferases activities, and pronounced prolongation in prothrombin time. In both cases, liver biopsy specimen examination revealed lesions compatible with drug-related injury. Other causes of hepatic injury were reasonably ruled out by complete careful screening. Outcome was marked by rapid complete recovery in one case and by slow recovery in the other. We suggest that simultaneous treatment with Atrium and paroxetine could increase each of these drugs' hepatotoxicity.

Publication Types:
  • Case Reports

PMID: 9916669 [PubMed - indexed for MEDLINE]