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Hyponatremia associated with
paroxetine.
Leung VP, Chiu HF, Lam
LC.
Department of Psychiatry, Chinese University of Hong
Kong.
Hyponatremia is an uncommon but widely reported
complication of selective serotonin uptake inhibitors (SSRIs), and most
of the case reports involve elderly patients. The presentation is
usually that of SIADH, but the underlying mechanism leading to the
syndrome is poorly understood. Since the use of SSRIs is becoming more
popular among elderly depressed patients and because of the potentially
serious consequence of hyponatremia, psychiatrists should be alert to
the development of the complication and familiarize themselves with its
diagnosis and treatment. We report two elderly patients who were
identified to have hyponatremia after the commencement of paroxetine.
This illustrates the need for monitoring of plasma sodium level if a
patient's clinical condition deteriorates. Other factors possibly
related to the hyponatremia are discussed and a review of the diagnosis
and management of SSRI-related hyponatremia is
included.
Publication Types:
PMID: 9524983 [PubMed - indexed for
MEDLINE]
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