Because of their favorable side effect profiles, selective serotonin reuptake inhibitors (SSRIs) are often prescribed for patients with depressive disorder. However, because of the inhibitory action on the Cytochrome-P 450 system (CYP450), SSRIs have variable drug interactions especially in combination with antipsychotic and antiarrhythmic drugs [1]. We present the first case report of bradycardia associated with a combination of paroxetine and carvedilol (Coreg) in a patient with depressive disorder.