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Reversible hepatotoxicity of
paroxetine in a patient with major
depression.
Helmchen C, Boerner RJ, Meyendorf R,
Hegerl U.
Department of Psychiatry, Ludwig Maximilians
University, Munich, Germany.
Selective serotonin reuptake
inhibitors (SSRIs) are becoming widely used because of their favorable
side-effect profile and their safety in overdose. We report about a
patient with recurring major depression (DSM-IIIR) who was treated with
paroxetine and developed a severe hepatotoxic reaction, which was
reversed after withdrawal of the drug. Individual, patient-related
causes for this side-effect were not found. To our knowledge, this is
the first published case of a probably paroxetine-induced severe
hepatotoxicity. Hepatotoxicity should be taken into account as a rare
complication that may occur not only with tricyclic antidepressants
(TCAs) but also with SSRIs.
Publication Types:
PMID: 8956353 [PubMed - indexed for
MEDLINE]
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