 About Entrez
Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
|
|
-
[Severe hepatitis attributed to
paroxetine (Seroxat)]
[Article in Dutch]
de
Man RA.
Academisch Ziekenhuis Rotterdam-Dijkzigt, afd. Maag-,
Darm- en Leverzieklen.
A 52-year-old man suffering from chronic
hepatitis B related liver cirrhosis was treated for depression with
paroxetine (Serotax) 5 mg and subsequently 15 mg once daily. A severe
hepatitis with liver failure (jaundice, hypoalbuminaemia, edemas, and
ascites) developed. After the drug was withdrawn the patient recovered
completely. The adverse reaction may be explained by a change in the
pharmacokinetics of the drug caused by the liver cirrhosis. Caution is
required in prescribing long-term paroxetine therapy for patients with
documented liver cirrhosis. The liver function should be monitored and
administration of the drug should be discontinued when functional
disturbances are noticed.
Publication Types:
PMID: 9190513 [PubMed - indexed for
MEDLINE]
|