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International Urogynecology Journal and Pelvic Floor Dysfunction
Publisher: Springer-Verlag London Ltd
ISSN: 0937-3462 (Paper) 1433-3023 (Online)
DOI: 10.1007/s001920070009
Issue: Volume 11, Number 6
Date:  November 2000
Pages: 386 - 388
Serotonergic Antidepressants and Urinary Incontinence

N. A. Votolato A1, S. Stern A2, R. M. Caputo A3

A1 Department of Psychiatry and Pharmacy, Ohio State University
A2 University of Texas, Health Science Center At San Antonio; San Antonio, Texas
A3 Division of Urogynecology and Pelvic Floor Reconstructive Surgery, Ohio State University, Columbus, Ohio, USA


Abstract: Many new serotonergic antidepressants have been introduced over the past decade. Although urinary incontinence is listed as one side effect of these drugs in their package inserts there is only one report in the literature. This concerns 2 male patients who experienced incontinence while taking venlafaxine. In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine. In 2 of the 3 cases the patients were also taking lithium carbonate and g-blockers, both of which could have contributed to the incontinence. Animal studies suggest that incontinence secondary to serotonergic antidepressants could be mediated by the 5HT4 receptors found on the bladder. Further research is needed to delineate the frequency of this troubling side effect and how best to treat it.


Key words:Antidepressants - Serotonin - Urinary incontinence

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