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Comment in:
Syndrome of inappropriate secretion of antidiuretic hormone
in two elderly women with elevated serum
fluoxetine.
Girault C, Richard JC, Chevron V,
Goulle JP, Droy JM, Bonmarchand G, Leroy J.
Medical Intensive
Care Unit, Charles Nicolle University Hospital, Rouen,
France.
OBJECTIVE: Fluoxetine is widely prescribed for depressed
patients. Hyponatremia secondary to inappropriate secretion of
antidiuretic hormone has been reported in a few cases associated with
routine use of fluoxetine, especially in elderly patients. The mechanism
has been postulated to be linked to the inappropriate secretion of
antidiuretic hormone. Serum concentrations of antidiuretic hormone and
fluoxetine have not been reported in previously published reports. CASE
REPORT: We report two new cases of severe and reversible hyponatremia
associated with routine use of fluoxetine therapy in two elderly women.
Fluoxetine-induced inappropriate secretion of antidiuretic hormone was
confirmed by elevated serum concentrations of antidiuretic hormone and
fluoxetine.
Publication Types:
PMID: 9022659 [PubMed - indexed for
MEDLINE]
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