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Acute hepatitis due to fluoxetine
therapy.
Cai Q, Benson MA, Talbot TJ, Devadas G,
Swanson HJ, Olson JL, Kirchner JP.
Department of General
Internal Medicine, Marshfield Clinic, Wis. 54449,
USA.
Fluoxetine-induced hepatotoxicity is generally considered of
minimal clinical importance and is not well recognized. Asymptomatic
increases in liver enzyme values have been observed in 0.5% of patients
who take long-term fluoxetine therapy. This report details 2 cases of
acute hepatitis believed to be caused by fluoxetine. Three cases of
acute hepatitis caused by fluoxetine have been reported previously. The
mechanism of fluoxetine-induced hepatotoxicity is unknown. Although
routine monitoring of liver function may not be cost-effective,
physicians should be alert to the possibility of fluoxetine-associated
hepatitis and consider early discontinuation of the drug if this
condition is suspected.
PMID: 10405699 [PubMed - indexed for
MEDLINE]
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