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Delirium during fluoxetine
treatment. A case report.
Leinonen E, Koponen H,
Lepola U.
Psychiatric Research Clinic of Kuopio,
Finland.
The correlation between high serum tricyclic
antidepressant concentrations and central nervous system side effects
has been well established. Only a few reports exist, however, on the
relationship between the serum concentrations of selective serotonin
reuptake inhibitors (SSRIs) and their toxic effects. In some cases, a
high serum concentration of citalopram (> 600 nmol/L) in elderly
patients has been associated with increased somnolence and movement
difficulties. Widespread cognitive disorders, such as delirium, have not
been previously linked with high blood levels of SSRIs. In this report,
we describe a patient with acute hyperkinetic delirium connected with a
high serum total fluoxetine (fluoxetine plus desmethylfluoxetine)
concentration.
Publication Types:
PMID: 8312983 [PubMed - indexed for
MEDLINE]
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