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Comment in:
Fluoxetine-induced bradycardia and syncope in two
patients.
Ellison JM, Milofsky JE, Ely
E.
Department of Psychiatry, Cambridge Hospital, MA
02139.
Fluoxetine appears to cause a low incidence of adverse
cardiac effects. An uncommon but potentially hazardous effect of
fluoxetine therapy, however, is bradycardia accompanied by faintness or
syncope. The authors report two cases in which this adverse effect
occurred. They hypothesize that the mechanism of bradycardia in these
cases represents a direct central nervous system effect of increased
serotonin on medullary cardiovascular regulation.
Publication
Types:
PMID: 2211552 [PubMed - indexed for
MEDLINE]
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