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1: Isr J Psychiatry Relat Sci. 1995;32(1):44-50. Related Articles, Links

Serotonin and suicidality: the impact of fluoxetine administration. II: Acute neurobiological effects.

Anderson GM, Segman RH, King RA.

Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.

Despite the demonstrated anti-depressant efficacy of the selective serotonin reuptake inhibitors (SSRIs), increased suicidal ideation and/or agitation have been reported in a small proportion of individuals receiving fluoxetine or other SSRIs. Part II of this review examines fluoxetine's acute effects on serotonergic functioning. Although acute fluoxetine administration produces a short-term compensatory decrease in the firing of 5-HT neurons, the neurobiological data reviewed suggests that this decrease probably does not lead to an over-compensatory net decrease in 5-HT functioning. The implications of fluoxetine's complex effects on the 5-HT systems are discussed with respect to clinical practices and future research.

Publication Types:
  • Review
  • Review, Tutorial

PMID: 7622346 [PubMed - indexed for MEDLINE]