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Fluoxetine and neuroleptic
malignant syndrome.
Halman M, Goldbloom
DS.
Department of Psychiatry, Toronto General Hospital,
University of Toronto, Canada.
The authors present a case report
of neuroleptic malignant syndrome (NMS) in a patient commencing
treatment with fluoxetine alone who had previously been treated with
several antipsychotic and antidepressant combinations. On reviewing the
literature on the pathogenesis of NMS, the authors hypothesize a
facilitative role of the neurotransmitter serotonin (5-HT) in
conjunction with central dopaminergic blockade in the precipitation of
NMS.
Publication Types:
PMID: 2223920 [PubMed - indexed for
MEDLINE]
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