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Melancholic symptoms during
concurrent olanzapine and fluoxetine.
Nelson LA,
Swartz CM.
St. Louis University School of Medicine,
Department of Psychiatry, Missouri 63104, USA.
lnelson@stlcop.edu
The concomitant use of olanzapine and
fluoxetine has been advocated for the treatment of various psychiatric
disease states. We describe a case in which the combination of
olanzapine and fluoxetine appears to have caused the psychopathology of
melancholic depression requiring hospitalization in a 40-year-old
female. Postulated mechanisms for this drug interaction, particularly
CYP450 isoenzyme inhibition by fluoxetine, is
discussed.
Publication Types:
PMID: 10984007 [PubMed - indexed for
MEDLINE]
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