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1: Rev Clin Esp. 2002 Apr;202(4):209-11. Related Articles, Links
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[Serotonin syndrome: report of a fatal case and review of the literature]

[Article in Spanish]

Bilbao Garay J, Mesa Plaza N, Castilla Castellano V, Dhimes Tejada P.

Servicio de Medicina Interna, Fundacion Hospital Alcorcon, Madrid, Spain.

We report here the case of a patient with fluoxetine and selegiline induced serotonin syndrome, which presented as encephalopathy, generalized myoclonias, fever, stiffness and sweating, complicated with acute renal failure, rhabdomyolysis and disseminated intravascular coagulation findings. The patient died 6 days after admission. This syndrome is discussed, with an analysis of its causes, pathophysiology and therapy. A special emphasis is placed on the clinical issues and differential diagnosis with the malignant neuroleptic syndrome and other clinical entities with which it could be mistaken. General recommendations are provided to avoid this poorly characterized syndrome that, as in our patient, may have a fatal outcome.

Publication Types:
  • Case Reports
  • Review
  • Review, Tutorial

PMID: 12003730 [PubMed - indexed for MEDLINE]