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[Serotonin syndrome:
report of a fatal case and review of the
literature]
[Article in Spanish]
Bilbao
Garay J, Mesa Plaza N, Castilla Castellano V, Dhimes Tejada
P.
Servicio de Medicina Interna, Fundacion Hospital Alcorcon,
Madrid, Spain. jbilbao@fhalcorcon.es
We report here the case of a
patient with fluoxetine and selegiline induced serotonin syndrome, which
presented as encephalopathy, generalized myoclonias, fever, stiffness
and sweating, complicated with acute renal failure, rhabdomyolysis and
disseminated intravascular coagulation findings. The patient died 6 days
after admission. This syndrome is discussed, with an analysis of its
causes, pathophysiology and therapy. A special emphasis is placed on the
clinical issues and differential diagnosis with the malignant
neuroleptic syndrome and other clinical entities with which it could be
mistaken. General recommendations are provided to avoid this poorly
characterized syndrome that, as in our patient, may have a fatal
outcome.
Publication Types:
- Case Reports
- Review
- Review, Tutorial
PMID: 12003730 [PubMed - indexed for
MEDLINE]
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