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Bupropion and anticonvulsant drug
interactions.
Popli AP, Tanquary J, Lamparella V,
Masand PS.
Cleveland VAMC, Ohio, USA.
The use of
bupropion (BUP) involves a higher seizure risk than the use of other
antidepressants, limiting its dose and widespread use. The two reported
cases document anticonvulsant-BUP drug interactions through plasma
levels. Carbamazepine appeared to decrease the plasma BUP to
nondetectable levels, while hydroxybupropion was found at very high
levels. Data presented suggest that BUP may increase sodium valproate
levels. Conclusions from these case reports are tentative, pending
further study. Monitering of BUP and its metabolites may ultimately
prove useful in guiding clinicians dosing decisions, especially when
mood stabilizers are combined with other psychotropic drugs in
refractory bipolar patients.
Publication Types:
PMID: 8556101 [PubMed - indexed for
MEDLINE]
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